Worthington concerns himself with painting as being a serious investigation into beauty, as well as a timeless medium able to withstand cultural and technological trends. His earlier practice delved into the complex narratives, drama, and techniques of the Northern, Italian, and Spanish Renaissance. For several years he explored Christian themes and portraiture, seeking to understand Caravaggio and his contemporaries. Upon seeing an exhibition of Rothko abstracts at the Tate Modern, Worthington began drawing parallels between those ancient paintings and what the Modernists were doing, believing that the two generations of artists approached art with the same integrity and conviction. His work began to take on a new hybridism of ancient and modern techniques, a continuous exploration of oils, with endless experimentations in glazing, layering, and non-conventional methods of paint application.